Education

I completed both my PhD and MSc in the Department of Genetics at Stellenbosch University under the supervision of Prof Louise Warnich.

PhD Genetics (2013): Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort. This project made use of:

  1. Exome sequencing of patients on extreme ends of the treatment response spectrum
  2. Prioritisation of variants that potentially contribute to antipsychotic treatment response using a bioinformatics pipeline
  3. Genotyping of prioritised variants in entire cohort using an Illumina BeadXpress assay
  4. Identification of the variants and pathways that are associated with antipsychotic treatment response.

MSc Genetics (2010): Detection of sequence diversity in the CYP2C19 gene of Xhosa South African individuals: An analytical and comparative study including in silico and functional analysis of the 5’ flanking region. This project made use of:

  1. Sanger sequencing for the identification of variants
  2. Dual luciferase reporter assays to asses the function of 5’ upstream variants
  3. Subsequent genotyping assays to examine the frequency of these variants in
    the South African Xhosa population.